The Butler men could not hold pace with Independence late, falling 85-77 to the Pirates at the Power Plant on Saturday afternoon.
That double-digit lead didn't last long and Indy tied the game with a bucket by Sean Pollock with 4:16 to go.
Independence would get a bucket with five seconds remaining and led Butler 32-30 at the half.
Butler scored the first four points of the second half to regain the lead. The Grizzlies would lead by six at 40-34 after a Juwan White basket with 17:20 to go.
Indy would answer with a 7-0 run to take a 41-40 lead. White hit a 3-pointer to briefly put Butler back in front 43-41. The two teams would go back-and-forth, and the game was tied several times, the latest at 77-77 with 1:47 remaining.
Independence would score the final eight points of the game to secure the win.
Butler's loss snaps a four-game winning streak. The Grizzlies are now 13-7 overall and 6-5 in Jayawk Conference play. The Grizzlies will be on the road Wednesday at Neosho County.